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Interaction of influenza virus with cell defence mechanisms
Vochyánová, Klára ; Drda Morávková, Alena (advisor) ; Mikušová, Gabriela (referee)
Influenza virus infection is one of the most current problems nowadays. Its unique ability to strongly inhibit cell immune response on many different levels and its pandemic potential make it a subject of interest of many research groups. The Influenza virus uses mainly NS1 protein to inhibit the immune response. NS1 protein is able, on one hand, to bind RNA and mask it against recognition by cellular sensors and other proteins. On the other hand, NS1 protein possesses a catalytic domain. Using this domain it interacts with many cellular proteins, interferes with signal transduction and guarantees successful infection. NS1 protein is one of principal pathogenicity instruments of the Influenza virus and it deserves appropriate attention.
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Interaction of influenza virus with cell defence mechanisms
Vochyánová, Klára ; Drda Morávková, Alena (advisor) ; Mikušová, Gabriela (referee)
Influenza virus infection is one of the most current problems nowadays. Its unique ability to strongly inhibit cell immune response on many different levels and its pandemic potential make it a subject of interest of many research groups. The Influenza virus uses mainly NS1 protein to inhibit the immune response. NS1 protein is able, on one hand, to bind RNA and mask it against recognition by cellular sensors and other proteins. On the other hand, NS1 protein possesses a catalytic domain. Using this domain it interacts with many cellular proteins, interferes with signal transduction and guarantees successful infection. NS1 protein is one of principal pathogenicity instruments of the Influenza virus and it deserves appropriate attention.
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Implementation of the National Action Plan to increase vaccination coverage against influenza in the district of Trutnov.
KISSOVÁ, Petra
Influenza is a highly contagious viral disease with epidemic and pandemic spread of the character, which annually affects 10% of the world's population, in the course of a pandemic even 40-50%. The originator of the disease is a virus that is present as a type A, type B or type C. Source of infection is the man to transfer air or contaminated objects. Susceptibility is widespread. The disease predominantly affects the respiratory tract, has a sudden beginning and manifests itself primarily with fever, chills, muscle pain, joint pain and headache. The most common complication is inflammation of the lungs. In the diagnosis are rapid tests for the detection of the Antigen. Treatment is symptomatic, antivirals are available the type of neuraminidase inhibitors M2, which easily gives rise to a resistance of influenza virus. The basis for the prevention of influenza is annual vaccination, which dramatically reduces the risk of hospitalization and death, especially among the elderly and the chronically ill. Coverage in our population is low, and that despite the fact that the flu is the cause of the deaths of thousands of people around the world. A year in the Czech Republic will die according to qualified estimates the flu one to two thousand people. Due to the possible prevention of influenza, it is important to disseminate information on the possibilities of prevention by vaccination and educate the general public about the seriousness of this disease. Diploma thesis discusses influenza disease as such and on the issue of vaccination against influenza among the elderly in connection with the adoption of the NAP to increase vaccination coverage against the flu. The theoretical part summarises the commonly known knowledge on the causative agent of the disease, the way of transmission, symptoms, diagnosis, complications, treatment, and prevention by vaccination.
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A new variation of influenza A ("Pandemic H1N1 2009") - the issue of awareness of vaccination among seniors.
BEČKOVÁ, Věra
The theme of my thesis is the issue of the new strain of influenza A (H1N1 Pandemic 2009) and the associated awareness of vaccination amongst the elderly. The work is divided into two parts, a theoretical and practical part. In the theoretical part, I tried to comprehensively process the available knowledge on the origins, epidemiology and prevention of influenza with particular emphasis on vaccination, oriented towards the elderly. The practical part is focused on mapping the awareness of the elderly of the issue of vaccination against influenza and analysis of results from a research exploratory investigation. The data acquisition method I used was quantitatively oriented research using anonymus questionnaires. Altogether, I distribued 350 questionnaires; the final number for data processing was 191 questionnaires. In connection with the work I set four hypotheses: 1) More than a third of respondents were vaccinated against the new strain of influenza A (H1N1 Pandemic 2009), 2) The most common reason for not being vaccinated was a lack of information. 3) The size of the place of residence significantly contributes statistically to a sense of awareness of respondents on this issue, 4) More than half of respondents would like to obtain more information on the issue of the new strain of influenza type A (Pandemic H1N1 2009). I confirmed or refuted the formulated the hypotheses based on survey evaluation. The results of the survey showed that most respondents do not feel that they are sufficiently informed about the issue of the new strain of influenza, and therefore discard the use of vaccinations. With this work I would like to stress the importance of information, which can help people consider the risks of influenza and motivate them to be vaccinated. Vaccination is an important means of protection against influenza viruses particulary for high-risk groups including the elderly. For this reason I consider the dissemination of information as very important and I hope that my thesis also serves this purpose.
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